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OCR: pressin is The major physiological function of vas e binds to a the concentration of urine. The hormor traluminal specific receptor (V2 receptor) on the cor lecting aspect of the tubular cells of the distal co losome X, duct of the nephron; its gene is on chron ate cAMP, Xq28. Adenyl cyclase is activated to gene e, resultingwhich in turn stimulates a protein kina ubule- and in rearrangement of intracellular micro tubular microfilaments. Consequently, luminal otonic pores (water channels) open to allow hy ell into the fluid in the nephron to flow across the c entrating hypertonic renal interstitium, thus conc the urine As the concentration of plasm w rate andvasopressin rises, a reduction in urine fl 3) occur. an increase in urinary osmolality (Fig. 5 Maximum antidiuresis occurs at plasma f ...